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RETINAL DEGENERATION

Focus on Therapy

*Friday, April 17th 2009*

13:00–13:05 Franz Badura (PRO RETINA Research Foundation, research division)
Welcome and opening remarks

13:05–13:15 Claus Gehrig (Chairman, PRO RETINA Deutschland e. V.)
"From the Patients View"

13:15–13:30 Eberhart Zrenner (Chairman, Scientific Medical Advisory Board)
"Retinal Degeneration – Focus on Therapy"

13:30–15:35 *Session 1: Molecular therapy in retinal degeneration – present and future*
Chairman: Prof. Bernhard Weber

# Scott Robbie, London: “Update on clinical trial of gene therapy for RPE65”

# Peter Humphries, Dublin: “Gene therapy of dominant RP”

# John Neidhardt, Zürich: "Gene therapy to rescue splice defects causing retinal degeneration"

# Uwe Wolfrum, Mainz: "Molecular genetic strategies for the treatment of Usher syndrome in the retina"

# Paul Lingor, Göttingen: “AAV-based gene therapy for de- and regeneration in the retina"

15:35–16:15 Coffee break and scientific chitchat

16:15–18:20 *Session 2: Cell-based therapy approaches in retinal degeneration*
Chairman: Prof. Peter Humphries

# Marius Ader, Dresden: “Retinal cell differentiation into mature photoreceptors”

# Mike Karl, Seattle: "Identification of neuronal precursor cells in the retina”

# Amanda Barber, London: “Development of improved protocols for photoreceptor cell transplantation”

# Raymond D. Lund, Oregon: “Photoreceptor progenitor cells in the treatment of retinal degeneration”

# Konrad Kauper, Neurotec, Rhode Island: “Experience with the CNTF clinical trial”

18:30 Dinner

19:30 *"Swingin’ Poster Session and Get Together”*

*Saturday, April 18th 2009*

8:30–10:10 *Session 3: Addressing microglia in retinal degeneration and therapy*
Chairman: Prof. Olaf Strauß

# Solon Thanos, Münster: “Microglia in retinal degeneration”

# Florian Sennlaub, Paris INSERM: “Chemokine receptor CX3CR1 in AMD”

# Jonathan Cooper, King’s College London: “Novel roles for glia in NCL pathogenesis”

# Thomas Langmann, Regensburg: “Modulation of microglia activity by dietary lipids”

10:10–11:00 Coffee break and scientific chitchat

11:00–12:15 *Session 4: Clinical trials - Planning, Implementation and Experience*
Chairman: Prof. Klaus Rüther

# Holger Lüdtke, Tübingen: "Study design and Randomization in clinical trials"

# Barbara Wilhelm, Tübingen: “Performance of clinical trials”

# Paulus deJong, Amsterdam: “Read-out and interpretation of clinical trials in retinal degeneration”

12:20–13:00 *Poster Awards and Short Presentations*

13:00 Lunch and end of meeting

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