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RP- und MD-Forschungspreise zur Verhütung von Blindheit

Liste der Preisträger 2016 bis 1985

RP-Preis 2016:
Herrn Dr. rer.nat. Elvir Becirovic, München:
1. Becirovic, E., S. Bohm, O.N. Nguyen, L.M. Riedmayr, M.A. Koch, E. Schulze, S. Kohl, O. Borsch, T. Santos-Ferreira, M. Ader, S. Michalakis, and M. Biel. 2016. In Vivo Analysis of Disease-Associated Point Mutations Unveils Profound Differences in mRNA Splicing of Peripherin-2 in Rod and Cone Photoreceptors. PLoS Genet. 12:e1005811.
2. Nguyen, O.N., S. Bohm, A. Giessl, E.S. Butz, U. Wolfrum, J.H. Brandstatter, C. Wahl-Schott, M. Biel, and E. Becirovic. 2016. Peripherin-2 differentially interacts with cone opsins in outer segments of cone photoreceptors. Hum. Mol. Genet.
3. Becirovic, E., O.N. Nguyen, C. Paparizos, E.S. Butz, G. Stern-Schneider, U. Wolfrum, S.M. Hauck, M. Ueffing, C. Wahl-Schott, S. Michalakis, and M. Biel. 2014. Peripherin-2 couples rhodopsin to the CNG channel in outer segments of rod photoreceptors. Hum. Mol. Genet. 23:5989-5997.

MD-Preis 2016:
Herrn Dr. rer. nat. Felix Grassmann, Regensburg:
1. Grassmann F, Cantsilieris S, Schulz-Kuhnt AS, White SJ, Richardson AJ, Hewitt AW, Vote BJ, Schmied D, Guymer RH, Weber BH, Baird PN. Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD). J Neuroinflammation 13:81, 2016
2. Fritsche LG*, Igl W*, Bailey JN*, Grassmann F*, Sengupta S*, et al. A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants. Nat Genet 48:134-43, 2016 (* = gleichberechtige Erstautoren)
3. Grassmann F, et al. A Candidate Gene Association Study Identifies DAPL1 as a Female- Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD). Neuromolecular Med 17:111-20, 2015.
4. Grassmann F, et al. A circulating microRNA profile is associated with late-stage neovascular age-related macular degeneration. PLoS One 9:e107461, 2014.

RP-Preis 2015:
Herrn Dr. rer. nat. Karsten Boldt, Tübingen:
1. Boldt K, Mans DA, Won J, van Reeuwijk J, Vogt A, Kinkl N, Letteboer SJF, Hicks WL, Hurd RE, Naggert JK, Texier Y, den Hollander AI, Koenekoop RK, Bennett J, Cremers FP, Gloeckner CJ, Nishina PM, Roepman R, Marius Ueffing (2011). Disruption of intraflagellar protein transport in photoreceptor cilia causes Leber congenital amaurosis in humans and mice. Journal of Clinical Investigation. 121: 2169-80
2. Texier Y, Toedt G, Gorza M, Mans DA, van Reeuwijk J, Horn N, Willer J, Katsanis N, Roepman R, Gibson TJ, Ueffing M, Boldt K. (2014) EPASIS: Elution profile analysis of SDS-induced sub-complexes by quantitative mass spectrometry. Molecular and Cellular Proteomics 13:1382-91

MD-Preis 2015:
Herrn Dr. med. Martin Gliem, Bonn:
1. Gliem M, Hendig D, Finger RP, Holz FG, Charbel Issa P. (2015) Reticular pseudodrusen associated with a diseased Bruch membrane in pseudoxanthoma elasticum. JAMA Ophthalmol. 133(5):581-8.
2. Gliem M, Müller PL, Mangold E, Bolz HJ, Stöhr H, Weber BH, Holz FG, Charbel Issa P (2015) Reticular Pseudodrusen in Sorsby Fundus Dystrophy. Ophthalmolgy [im Druck, online publiziert].

RP-Preis 2014:
Dr. rer.nat. Marcus Karlstetter, Köln:
Karlstetter M et al., Disruption of the retinitis pigmentosa 28 gene Fam161a in mice affects photoreceptor ciliary structure and leads to progressive retinal degeneration. Hum Mol Genet. 2014 May 15. Pii; ddu242. [Epub ahead of print].

MD-Preis 2014:
Dr. Dr. Barbara Maria Braunger:
1. Braunger B.M. et al. (2013), Constitutive overexpression of Neurin activates Wnt/ß-catenin and endothelin-2 signaling to protect photoreceptors from light damage. Neurobiol. Dis. 50, 1-12.
2. Braunger et al. (2013), TGF-ß signaling protects retinal neurons from programmed cell death during the development of the mammalian eye. J. Neurosci. 33, 14246-58.

RP-Preis 2013:
PD Dr. Heidi Stöhr:
1. Zach F, Grassmann F, Langmann T, Sorusch N, Wolfrum U, Stöhr H. The
retinitis pigmentosa 28 protein FAM161A is a novel ciliary protein involved in
intermolecular protein interaction and microtubule association. Hum Mol
Genet. 21:4573-86 (2012); IF2011 = 7.636

2. Langmann T, Di Gioia SA, Rau I, Stöhr H, Maksimovic NS, Corbo JC, Renner AB, Zrenner E, Kumaramanickavel G, Karlstetter M, Arsenijevic Y, Weber BH, Gal A, Rivolta C. Nonsense mutations in FAM161A cause RP28-associated recessive retinitis pigmentosa. Am J Hum Genet. 87:376-81 (2010); IF2011 = 10.603

MD-Preis 2013:
Dr. rer. Nat. Dominik Eberle:
1. Eberle D, Schubert S, Postel K, Corbeil D, Ader M (2011) Increased integration of transplanted CD73-positive photoreceptor precursors into adult mouse retina. IOVS, 52(9):6462-71.
2. Eberle D, Kurth T, Santos-Ferreira T, Corbeil D, Ader M (2012) Outer segment formation of transplanted photoreceptor precursor cells. PLoS One, 7(9): e46305.

RP-Preis 2012:
Dr. phil. Nat. Kerstin Nagel-Wolfrum, Mainz:
1. Tobias Goldmann, Annie Rebibo-Sabbah, Nora Overlack, Igor Nudelman, Valery Belakhoy, Timor Baasov, Tamar Ben-Yosef, Uwe Wolfrum und Kerstin Nagel-Wolfrum: Beneficial Read-Through of a USH1C Nonsense Mutation by Designed Aminoglycoside NB30 in the Retina. Investigative Ophthalmology & Visual Science, 51:6671-6680 (2010)
2. Tobias Goldmann, Nora Overlack, Uwe Wolfrum und Kerstin Nagel-Wolfrum: PTC124-Mediated Translational Read through of a Nonsense Mutation Causing Usher Syndrome Type 1C. Human Gene Therapy 22:537-547 (2011)

MD-Preis 2012:
PD Dr. med. Tim U. Krohne, Bonn:
Tim U. Krohne, Peter D. Westenskow, Toshihide Kurihara, David F. Friedlander, Mandy Lehmann, Alison L. Dorsey, Wenlin Li, Saiyong Zhu, Andrew Schultz, Junhua Wang, Gary Siuzdak, Sheng Ding, Martin Friedlander: Generation of Retinal Pigment Epithelial Cells from Small Molecules and OCT4 Reprogrammed Human Induced Pluripotent Stem Cells. Stem Cells – Translational Medicine 1:96-109 (2012)

R P-Preis 2011:
Dr. phil. Volker Busskamp, Basel:
Busskamp V, Duebel J, Balya D, Fradot M, Viney T J, Siegert S, Groner A C, Cabuy E, Forster V, Seeliger M, Biel M, Humphries P, Paques M, Mohand-Said S, Trono D, Deisseroth K, Sahel J A Picaud,S, Roska B: Genetic Reactivation of Cone Photoreceptors Resotves Visual Responses in Retinitis Pigmentosa. Science 329:413-417 (2010)

MD-Preis 2011:
Dr. rer. nat. Ulrike Friedrich, Regensburg:
1. Friedrich U., Stöhr, H, Hilfinger D., Loenhardt T., Schachner M., Langmann T., Weber B H (2011) The Na/K-ATPase is obligatory for membrane anchorage of retinoschisin, the protein involved in the pathogenesis of X-linked juvenile retinoschisis. Hum.Mol. Genet. 20(6):1132-1142. IF2010 7.386
2. Friedrich U., Myers C A, Fritsche L G, Melenkovich A., Wolf A., Corbo J C, Weber B H (2011) Risk- and non-risk-associated variants at the 10q26 AMD locus influence ARMS2 mRNA expression but exclude pathogenic effects due to protein deficiency. Hum. Mol. Genet. 20(7):1387-1399. IF2010 7.386

RP-Preis 2010:
Dr. Andreas Ohlmann, Regensburg:
1. Ohlmann A, Seitz R, Braunger B, Seitz d, Bösl MR, Tamm ER: Norrin Promotes Vascular Regrowth after Oxygen-Induced Retinal Vessel Loss and Suppresses Retinopathy in Mice. J. Neurosci, 30(1): 183-193 (2010)
2. Seitz R, Hackl S, Seibuchner T, Tamm E, Ohlmann A: Norrin Mediates Neuroprotective Effects on Retinal Ganglion Cells via Activation of the Wnt/ß-Catenin Signaling Pathway and the Induction of Neuroprotective Growth Factors in Müller Cells. J. Neurosci 30(17): 5998-6010 (2010)
MD-Preis 2010:
nicht vergeben

RP-Preis 2009:
Dr. Marijana Samardzija, Zürich:
1. Samardzija M, Wenzel A, Naash M, Remé C, Grimm C. Rpe65 as a modifier gene for inherited retinal degeneration. Eur J Neurosci, 23: 1028-1034 (2006)
2. Samardzija M, Wenzel A, Thiersch M, Frigg, R, Remé C, Grimm C. Caspase-1 ablation protects photoreceptors in a model of autosomal dominant retinitis pigmentosa. Invest Ophthalmol Vis Sci, 47: 5181-8190 (2006)
3. Samardzija M, Wenzel A, Aufenberg S, Thiersch M, Remé C, Grimm C. Differential role of Jak-STAT signaling in retinal degenerations. FASEB J, 20: 2411-2413 (2006).

MD-Preis 2009:
Lars Fritsche, Regensburg:
1. Fritsche L.G., Loenhardt T., Janssen A., Fisher S.A., Rivera A., Keilhauer C.N., Weber B.H. (2008). Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA. Nat. Genet. 40, 892-6
2. (2009). Age-related macular degeneration and functional promoter and coding variants of the apolipoprotein E gene. Hum. Mutat. 30, 1048-53

RP-Preis 2008:
Dr. Tina Märker, Mainz:
A novel Usher protein network at the periciliary reloading point between molecular transport machineries in vertebrate photoreceptor cells, published by Tina Merker, Erwin van Wijk, Nora Overlack, Ferry F. J. Kersten, JoAnn McGee, Tobias Goldmann, Elisabeth Sehn, Ronald Roepman, Edward J. Wash, Hannie Kremer and Uwe Wolfrum Human Molecul Genetics, 17:71-86, 2008

MD-Preis 2008:
Dr. Monika Fleckenstein, Bonn:
1. M. Fleckenstein, P. Charbel Issa, H.-M. Helb, S. Schmitz-Valckenberg, R.P. Finger, JH.P.N: Scholl, K. U. Loeffler, F.G. Holz. High resolution Spectral Domain-OCT imaging in Geographic Atrophy associated with Age-related Macular Degeneration. Invest Ophthalmol Vis Sci. (2008), in press
2. M. Fleckenstein, P.Charbel Issa, H.A.Fuchs, R.P. Finger, H.-M. Helb, H.P.N. Scholl, F.G. Holz. Discrete arcs of increased fundus autofluorescence in retinal dystrophies and functionla correlate on microperimetry. Eye. (2008), 1-9

RP-Preis 2007:
Inga Ebermann, Köln:
1. Ebermann I, Scholl HPN, Charbel Issa P, Becirovic E, Lamprecht J, Jurklies B, Millan JM, Aller E, Mitter D, Bolz H: A novel gene for Usher syndrome type 2: mutations in the long isoform of whirlin are associated with retinitis pigmentosa and sensorineural hearing loss. Hum Genet, 121(2):203-211 (2007)

2. Ebermann I, Walger M, Scholl HPN, Issa PC, Luke C, Nurnberg G, Lang-Roth R, Becker C, Nurnberg P, Bolz HJ: Truncating mutation of the DFNB59 gene causes cochlear hearing impairment and central vestibular dysfunction. Hum Mutat, 28(6):571-577 (2007)

MD-Preis 2007:
Dr. Peter Charbel Issa, Bonn:
1. Charbel Issa P, Helb HM, Rohrschneider K, Holz FG, Scholl HPN. Microperimetric Assessment of Patients with Type II Macular Telangiectasia. Invest Ophthalmol Vis Sci, Vol. 48 (8):3788-3795 (2007)
2. Charbel Issa P, Scholl HPN, Holz FG (2007) Findings in Fluorescein Angiography and Optical Coherence Tomography after Intravitreal Bevacizumab in Type 2 Idiopathic Macular Telangiectasia. Ophthalmology Vol. 114 (9): 1736-1742 (2007)

RP-Preis 2006:
Dr. Christina Zeitz, Zürich:
Mutations in the GRM6 Cause Autosomal Recessive Congenital Stationary Night Blindness with a Distinctive Scotopic 15-Hz Flicker Electroretinogram
(Investigative Ophthalmology&Visual Science 46, 11:4328-4335, 2005)

MD-Preis 2006:
Dr. Sabine Aisenbrey, Tübingen:
Retinal pigment epithelial cells synthesize laminins including laminin 5 and adhere to them using α3- and α 6-containing integrins

RP-Preis 2005:
nicht vergeben

MD-Preis 2005:
Dr. Marc Steffen Schmitz-Valckenberg, Bonn: Fundus Autofluorescence and Fundus Perimetry in the Junctional Zone of Geographic Atrophy in Patients with Age-Related Macular Degeneration

RP-Preis 2004:
Dr. A. Janecke, Innsbruck: Mutations in RDH12 encoding photoreceptor cell retinal dehydrogenase cause severe childhood-onset retinal dystrophy

MD-Preis 2004:
Dr. A. Marneros, Boston: Collagen XVIII/endostatin is essential for vision and retinal pigment epithelial function

RP-Preis 2003:
Dr. C. Grimm und Dr. A. Wenzel, Zürich: Role of the rhodopsin and RPE 65 in light-induced retinal degeneration
MD-Preis 2003:
Dr. H. Scholl, London / Tübingen: Alterations of slow and fast rod ERG signals in patients with molecularly confirmed Stargardt disease type 1

RP-Preis 2002:
Dr. Norbert Kinkl, München: Aufklärung des Wirkungsmechanismus des basischen Fibroblasten Wachstumsfaktors (FGF 2) auf das Überleben von Photorezeptoren und seine intrazelluläre Signaltransduktion in der Rattenretina

MD-Preis 2002:
nicht vergeben

RP-Preis 2001:
Dr. med. Hanno Bolz, Hamburg: Identifizierung des Gens für das Usher-Syndrom Typ I D

MD-Preis 2001:
Dr. med. Florian Schütt, Heidelberg: Phototoxische Eigenschaften von Biomolekülen in Lipofuszingranula

RP-Preis 2000:
Dr. Farhad Hafezi, Zürich: Differential DNA-binding activities of the transcription factors AP-1 and OCT-1 during light-induced apoptosis of photoreceptors

MD-Preis 2000:
Prof. Dr. Ursula Schmidt-Erfurth, Lübeck: Photodynamic Therapy of subfoveal chorodial neovascularisation in age related macular degeneration with verteporfin

RP-Preis 1999:
Dr. Mathias Seeliger, Tübingen: Erstbeschreibung einer hereditären Netzhautdystrophie, verursacht durch einen genetischen Defekt im Retinolstoffwechsel

MD-Preis 1999:
PD Dr. med. Frank Holz, Heidelberg: Altersabhängige Makuladegeneration

Bis 1998 wurde ein Preis vergeben für die Netzhautforschung:
PD Dr. Ulrich Kellner, Berlin: Klinische und physiologische Differenzierungen hereditärer Netzhautdystrophien

Dr. Wolfgang Berger, Berlin und Dr. Thomas Meitinger, München: Identifizierung und molekulargenetische Analyse von Genen x-chromosomaler Netzhautdegenerationen

PD Dr. Bernhard Weber, Würzburg: Molekulargenetische Aufklärung der Fundusdystrophie vom Typ Sorsby

Dr. Olaf Strauß, Ingelheim: Rolle der Calciumkanäle bei erblichen Netzhautdegenerationen

Dr. Solon Thanos, Tübingen: Rolle der Mikroglia bei degenerativen Erkrankungen der Netzhaut

Frans. P. M. Cremers, Nijmegen: Identifizierung und molekulargenetische Analyse des Gens für Chorioideremie

Dr. E. Brischnik, Zürich: Dokumentation der Symptomatik bei Konduktorinnen mit x-chromosomaler RP

Dr. Andreas Gal, Bonn: Molekulargenetische Analyse und Kartierung der Gene der x-chromosomal vererbten Retinopathia Pigmentosa

Dr. Marion S. Eckmiller, Düsseldorf und Dr. J. Gottlob, Wien: Morphogenese der Photorezeptorenaußensegmente

Dr. K. W. Koch, Jülich: Molekulare Grundlagen der Photorezeptoren

Prof. Dr. E. El-Hifnawi, Lübeck: Pathomorphologische Untersuchungen zum Verlauf der hereditären Netzhautdystrophie bei RCS-Ratten

Dr. T. Schneider, München: Einfluss von Phosphodisterase-Hemmstoffen auf die Netzhautfunktion des arteriell perfundierten Auges


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